RNA Details
Disease Name
non-alcoholic fatty liver disease
Tissue
liver
RNA Symbol
Ppp1cc
RNA ID
RNA Type
mRNA
Alteration Pattern
phosphatase pp1c
Species
mus musculus
Detection Methods
hyperinsulinemic-euglycemic clamp studies; immunoprecipitation; immunoblot etc.
Target
PP1C
Pathway
PHOSPHO-EIF-2A KINASE-MEDIATED STRESS
PubMed ID
Title
"Hepatocyte Nicotinamide Adenine Dinucleotide Phosphate Reduced Oxidase 4 Regulates Stress Signaling, Fibrosis, and Insulin Sensitivity During Development of Steatohepatitis in Mice"
Year
2015
Function
Sirt2;Erk;C-myc axis in promoting hepatic fibrogenesis. Inhibition of the sirt2;Erk;C-myc axis represents a novel strategy to prevent and to potentially treat liver fibrosis and cirrhosis.